The burden of coronary heart disease (CHD) is increasing at a greater rate in South Asia than in any other region globally, but there is little direct evidence about its determinants. The Pakistan Risk of Myocardial Infarction Study (PROMIS) (PI: Danish Saleheen) is an epidemiological resource to enable reliable study of genetic, lifestyle and other determinants of CHD in South Asia. By 2017, PROMIS had recruited over 21,000 cases of first-ever confirmed acute myocardial infarction (MI) and over 21,000 matched controls aged 30-80 years. For every participant, information has been recorded on ≈300 characteristics, including lifestyle (eg, diet, tobacco consumption, physical activity) factors, medical history, anthropometry, lipids, and HbA1c. More than 200 further soluble biomarkers in lipid, metabolic and other pathways have been assayed, and 400 endogenous metabolites have been assayed in 5,000 participants using LCMS-metabonomics. A genomewide association study (GWAS) has been completed in the initial 18,000 participants, and 3 customized gene arrays (50K "cardiochip", 200K "metabochip" and "exome-chip") have been completed in up to 25,000 participants. In a few hundred participants, collection has been completed of RNA from monocytes to enable mechanistic sub-studies.