Age related macular degeneration (ARMD) is one of the leading causes of visual impairment in individuals more than 50 years of age in developed countries. It is the major challenge in the new millennium in the developing countries also, as the size of the elderly population continues to rise due to betterment of medical facilities and increased life expectancy. ARMD was found to be the second only to cataract as the cause of sever visual loss even in South Asian countries. ARMD is associated with depressive disorders in addition to visual disability. In a recent series, 32.5% of ARMD patients were found to suffer from depressive disorders in addition to visual disability. To prevent the age related macular changes and to enhance functioning of this segment of population, the knowledge of epidemiology and risk factors for ARMD is important. PRAISE aims to identify risk factors that increase the risk of ARMD in Pakistani population. This study has enrolled >500 confirmed participants with ARMD and >500 controls. For every participant, information has been recorded on ≈200 characteristics, including lifestyle (eg, diet, tobacco consumption, physical activity) factors, medical history, anthropometry and lipids.