Co-Director

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Dr. Philippe M. Frossard has been the co-Director of the Center for Non-Communicable Diseases since 2008. He received his B.Sc. (1975), M.Sc. (1976), M.Phil. (1977), and Ph.D. (1979), all with honors from the faculties of Sciences and Medicine of the University Louis Pasteur in Strasbourg, France. In 1996, he was awarded a D.Sc. from his alma mater for his lifetime achievements.

Dr. Frossard is a medical scientist who comes to the CNCD with a wealth of scholarly, teaching and administrative experience in the United States, England, Japan, France, Australia, Pakistan and the United Arab Emirates. From 2009 until March 2011, he was the Dean of the College of Arts and Sciences at Abu Dhabi University, UAE, where he also served as Acting Provost and Acting Vice-Chancellor.

From 2001 to 2009, Dr. Frossard was the Abdulaziz Hussainali Sharif Endowed Professor and Chairperson in the Department of Biological and Biomedical Sciences, at the Medical College of Aga Khan University in Pakistan. From 1993 to 2001, he served as Associate Professor and Deputy Chair of the Department of Pathology at UAE University in the UAE.

From 1983 to 1990, Dr. Frossard worked at California Biotechnology, Inc., California, USA, where he served as Senior Scientist and Director of the Division of Molecular Genetics (1987–1990). Prior to that, he served as Medical Research Fellow (1981–1983) in the Department of Human Genetics at the University of Michigan Medical Center, Ann Arbor, USA.

Dr. Frossard has published extensively on cardiovascular and coronary diseases in a number of prestigious journals. He has received over 40 grants to research topics ranging from the causes of heart diseases to genetic determinants of diabetes and stroke. He holds several medical patents.

He has received awards from major international bodies, including UNESCO’s World’s Young Scientist Award, which he won in 1971, and the Chevalier de l’Ordre National du Mérite (Knight of the National Order of Merit), conferred on him by France in 2003.

Selected Publications

    1. Saxena R, Saleheen D, Been LF, et al. Genome-Wide Association Study Identifies a Novel Locus Contributing to Type 2 Diabetes Susceptibility in Sikhs of Punjabi Origin from India. Diabetes 2013 (Jan 8).

 

    1. Chen YC, et al., on behalf of the International Stroke Genetics Consortium. Are myocardial infarction-associated single-nucleotide polymorphisms associated with ischemic stroke? Stroke 2012; 43(4): 980-986.

 

    1. Khan M, Rasheed A, Hashmi S, Zaidi M, Murtaza M, Akhtar S, Bansari L, Shah N, Samuel M, Raza S, Khan UR, Ahmed B, Ahmed B, Ahmed N, Ara J, Ahsan T, Munir SM, Ali S, Mehmood K, Makki KU, Ahmed MM, Sheikh N, Memon AR, Frossard PM, Kamal AK. Stroke radiology and distinguishing characteristics of intracranial atherosclerotic disease in native South Asian Pakistanis. International Journal of Stroke 2012 (Sep 27); doi: 10.1111/j.1747-4949.2012.00878.x.

 

    1. Voight BF, Peloso GM, Orho-Melander M, et al. Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomization study. The Lancet 2012; 380(9841): 572-580.

 

    1. Kelly MA, Rees SD, Hydrie MZ, Shera AS, Bellary S, O’Hare JP, Kumar S, Taheri S, Basit A, Barnett AH; Diagram Consortium; SAT2D Consortium (225 Collaborators). Circadian gene variants and susceptibility to type 2 diabetes: a pilot study. PLoS One2012; 7(4): e32670.

 

    1. Ur-Rehman S, Sadiq MA, Parekh MA, Zubairi ASB, Frossard PM, Khan JA. Cross-sectional study identifying forms of tobacco used by shisha smokers in Pakistan. Journal of the Pakistan Medical Association 2012; 62: 192-195.

 

    1. Clarke R, et al., MTHFR Studies Collaborative Group. Homocysteine and coronary heart disease: meta-analysis of MTHFR case-control studies, avoiding publication bias. PLoS Medicine 2012; 9(2): e1001177.

 

    1. IBC 50K CAD Consortium. Large-scale gene-centric analysis identifies novel variants for coronary artery disease. PLoS Genetics 2011; 7(9): e1002260

 

    1. Kooner JS, Saleheen D, Sim X, Sehmi J, Zhang W, Frossard P, et al. Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci. Nature Genetics 2011; 43(10): 984-989.

 

    1. C Reactive Protein Coronary Heart Disease Genetics Collaboration (CCGC). Association between C reactive protein and coronary heart disease: Mendelian randomization analysis based on individual participant data. British Medical Journal 2011; 342: d548.

 

    1. The Coronary Artery Disease (C4D) Genetics Consortium. A genome-wide association study in Europeans and South Asians reveals five novel loci for coronary artery disease. Nature Genetics2011; 43(4): 339-344.

 

    1. International Stroke Genetics Consortium; Wellcome Trust Case-Control Consortium 2. Failure to validate association between 12p13 variants and ischemic stroke. The New England Journal of Medicine 2010; 362(16): 1547-1550.

 

    1. Saleheen D, et al. Genetic determinants of major blood lipids in Pakistan is compared with Europeans. Circulation: Cardiovascular Genetics 2010 (PMID: 20570915); 3(4): 348-357.

 

    1. Saleheen D, et al. Association of the 9p21.3 locus with risk of first-ever myocardial infarction in Pakistanis: case-control study in South Asia and updated meta-analysis of Europeans. Arteriosclerosis, Thrombosis and Vascular Biology 2010; 30(7): 1467-1473.

 

    1. Triglyceride Coronary Disease Genetics Consortium and Emerging Risk Factors Collaboration. Triglyceride-mediated pathways and coronary disease: collaborative analysis of 101 studies. The Lancet2010; 375(9726): 1634-1639.

 

    1. Saleheen D, Hashmi SK, Zaidi M, Rasheed A, Murtaza M, Abbas A, Nasim S, Hameed MQ, Shuja F, Sethi MJ, Hussain I, Shahid K, Khalid H, Ahmad U, Kastelein JJ, Frossard PM, Ishaq M. Evaluation of therapeutic control in a Pakistani population with hypertension. Journal of Evaluation in Clinical Practice 2010; PMID: 20629998.

 

    1. Umedani LV, IshaqAiwan M, Ahmad U, Mehraj VK, Frossard PM. Prevalence of cardiovascular diseases and essential hypertension in the desert area of Thar. Pakistan Journal of Medical Research 2010; 49(3): 63-70.

 

    1. Burgess S, Thompson SG, and the CRP CHD Genetics Collaboration. Bayesian methods for meta-analysis of causal relationships estimated using genetic instrumental variables. Statistics in Medicine 2010; 29(12): 1298-1311.

 

    1. Coronary Artery Disease Consortium (Samani NJ et al., incl. Frossard PM). Large scale association analysis of novel genetic loci for coronary artery disease. Arteriosclerosis, Thrombosis and Vascular Biology 2009; 29(5): 774-80.

 

    1. Shah U, Frossard P, Moatter T. Cystic fibrosis: defining a disease under-diagnosed in Pakistan. Tropical Medicine and International Health 2009; 14(5): 542-545.

 

    1. Kamal AK, Taj F, Junaidi B, Rasheed A, Zaidi M, Murtaza M, Iqbal N, Hashmat F, Alam SV, Saleem U, Waheed S, Bansari L, Shah N, Sameul M, Yameen M, Naz S, Khan FS, Ahmed N, Mahmood K, Sheikh N, Makki KU, Ahmed MM, Memon AR, Wasay M, Syed NA, Khealani B, Frossard PM, Saleheen D. The Karachi intracranial stenosis study (KISS) protocol: an urban multi-center case-control investigation reporting the clinical, radiologic and biochemical associations of intracranial stenosis in Pakistan. BioMed Central Neurology 2009; 9(1):31.

 

    1. Saleheen D, Zaidi M, Rasheed A, Ahmad U, Hakeem A, Murtaza M, Kayani W, Faruqui A, Kundi A, Zaman KS, Yaqoob Z, Cheema LA, Samad A, Rasheed SZ, Mallick NH, Azhar M, Jooma R, Gardezi AR, Memon N, Ghaffar A, Fazal-ur-Rehman, Khan N, Shah N, Ali Shah A, Samuel M, Hanif F, Yameen M, Naz S, Sultana A, Nazir A, Raza S, Shazad M, Nasim S, Javed MA, Ali SS, Jafree M, Nisar MI, Daood MS, Hussain A, Sarwar N, Kamal A, Deloukas P, Ishaq M, Frossard P, Danesh J. The Pakistan Risk of Myocardial Infarction Study: a resource for the study of genetic, lifestyle and other determinants of myocardial infarction in South Asia.European Journal of Epidemiology 2009; 24(6): 329-38.

 

    1. CRP CHD Genetics Collaboration (Danesh J et al.). Collaborative pooled analysis of data on C-reactive protein gene variants and coronary disease: judging causality by Mendelianrandomisation. European Journal of Epidemiology 2008; 23(8): 531-540.

 

    1. Rabbani MA, Mahmood SM, Mekan SF, Frossard PM. Association of Angiotensin-converting enzyme gene dimorphisms with severity of lupus disease. Saudi Journal of Kidney Disease and Transplantation 2008; 19(5): 761-766.

 

    1. Saleheen D, Ali A, Khanum S, Ozair MZ, Sethi MJ, Khan N, Frossard P. Molecular analysis of the XLRS1gene in four females affected with X-linked juvenile retinoschisis. Canadian Journal of Ophtalmology2008; 43(5): 596-599.

 

    1. Khawaja MR, Taj F, Saleheen D, Ahmad U, Chohan MO, Jafar T, Frossard PM. Association study of two interleukin-1 gene loci with essential hypertension in a Pakistani Pathan population. Journal of Human Hypertension 2008; 22(1): 60-2.
    2. Kazim SF, Salman MB, Zubairi AJ, Afzal A, Ahmad U, Frossard PM. Offsprings of hypertensive parents have higher blood pressure and BMI. Journal of the College of Physicians and Surgeons Pakistan 2008; 18(1): 64-65.

 

    1. Khan A, Haq FU, Pervez MB, Saleheen D, Frossard P, Ishaq M, Hakeem A, Sheikh HT, Ahmad U. Anthropometric correlates of blood pressure in normotensive Pakistani subjects. International Journal of Cardiology 2008; 124(2): 259-262.

 

    1. Saleheen D, Frossard PM. The cradle of Cystic Fibrosis Trans-membrane Conductance Regulator gene deltaF508 mutation (Review). Journal of the Ayub Medical College Abbottabad 2008; 20(4): 157-160.