About Us
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About Us

Welcome to the Center for Non-Communicable Diseases

Non-Communicable Diseases such as coronary heart diseases, diabetes mellitus, stroke and cancers are the leading cause of disability and death worldwide. Burden on health due to these disorders is particularly increasing in developing countries, particularly among the 1.5 billion people in South Asia. The Center for Non-Communicable Diseases (CNCD), Pakistan (led by Dr. Danish Saleheen) is an independent research institute that is conducting detailed investigations to identify genetic, lifestyle and blood based factors that cause these disorders.


In-particular, CNCD has already collected various biological specimens (including DNA and RNA) and recorded extensive lifestyle, clinical and demographic information from >40,000 participants enrolled from thirteen urban cities in Pakistan. CNCD has a staff of >80 which includes medical physicians, laboratory research associates, field nurses, and data-entry operators, who enroll >10,000 participants each year. Our aim is to investigate these complex disorders through a multi-disciplinary approach by integrating clinical epidemiology, genomics, proteomics and experimental biology:

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Welcome to the Center for Non-Communicable Diseases

Non-Communicable Diseases such as coronary heart diseases, diabetes mellitus, stroke and cancers are the leading cause of disability and death worldwide. Burden on health due to these disorders is particularly increasing in developing countries, particularly among the 1.5 billion people in South Asia. The Center for Non-Communicable Diseases (CNCD), Pakistan (led by Dr. Danish Saleheen) is an independent research institute that is conducting detailed investigations to identify genetic, lifestyle and blood based factors that cause these disorders.

Genomics

Through collaboration with various international institutes, we have conducted detailed genetic investigations on the participants that we have enrolled. These state-of-the art genetic approaches include whole-genome sequencing, genome-wide association studies (GWAS), and genotyping using Cardio-Metabochip and IBC-arrays. We have recently finished collecting information on >8 million genetic markers on 22,500 participants through GWAS.

Blood Based Factors

We are analysing greater than 60 blood based factors related to various biological pathways including lipids, metabolism, insulin resistance, hemostasis and inflammation. Moreover, we have employed more novel approaches such as mass-spectroscopy and functional assays which have not been previously investigated in large epidemiological studies.

Multi-Disciplinary Approach

The unique aspect of these investigations is the availability of data on lifestyle, genomics and blood based factors on the same participants providing unprecedented opportunities to make novel biological discoveries.