Welcome to the Center for Non-Communicable Diseases
Non-Communicable Diseases such as coronary heart diseases, diabetes mellitus, stroke and liver diseases are the leading cause of disability and death worldwide. Burden on health due to these disorders is particularly increasing in developing countries, particularly among the 1.5 billion people in South Asia. The Center for Non-Communicable Diseases (CNCD), Pakistan is an independent research institute that is conducting detailed investigations to identify genetic, lifestyle and blood based factors that cause these disorders. The institute has already established a bio-bank involving > 65,000 participants which is rapidly being expanded to 200,000 participants. We are particularly leveraging the high levels of consanguinity in Pakistan to identify "Human Knockouts" (i.e., individuals homozygous null for a loss of function (LoF) mutation); detailed phenotyping in such individuals could rapidly transform medicine development.